Fermentation Process Development

We provide comprehensive fermentation process development services to customers to transform promising microbial production systems into robust, efficient, and scalable processes. We optimize key process parameters to maximize productivity, yield, and product quality.

Examples of microorganisms for which we have developed and optimized fermentation processes include Aspergillus oryzae, Trichoderma reesei, Pichia pastoris, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus rhamnosus, Chlamydomonas reinhardtii.

Our fermentation process development services include:

Media Development: Systematic optimization of carbon and nitrogen sources, minerals, trace elements, antifoams, and other process-specific components to support high cell density, enhance product formation, maximize yield, and ensure robust and consistent fermentation performance with design of experiments in laboratory and pilot scale.

Process Optimization: We systematically optimize critical fermentation parameters—including pH, temperature, dissolved oxygen, agitation, aeration, feeding, and process timing—to improve productivity and process robustness.

Upstream Process Development: From inoculum development and seed-train strategies to fermentation optimization, we develop reproducible upstream processes tailored to your microbial production system.

Downstream Process Integration: We consider downstream requirements during process development to ensure efficient recovery and purification of the target product and maximize overall process yield.

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Fermentation Process Development