Livzym · Manufacturing platform
Capabilities
An integrated precision fermentation facility: 200 m³ of installed vessel capacity, automated downstream processing and in-house spray drying, all under one roof.
Livzym’s integrated manufacturing facility supports the development and commercial production of enzymes, alternative proteins and postbiotics through precision fermentation. Our platform includes a total installed vessel capacity of 200 m³. Automated downstream processing, diverse filtration and separation technologies, and in-house pilot- and commercial-scale spray drying enable integrated production.
Upstream
Our pilot-to-production fermentation platform spans 30 L to 50,000 L and is designed to reproduce key process conditions across scales. This supports systematic scale-up studies, reliable process transfer, and the development of robust, scalable processes for efficient commercial manufacturing.
Details
- Pilot bioreactors: 30 and 300 L stainless steel, stirred fermenters.
- Production bioreactors: 1 × 30 m³, 3 × 20 m³ and 2 × 50 m³ stainless steel, stirred fermenters.
- Seed fermenters and buffer tanks in a range of capacities.
- High-power agitation systems for intensive mixing.
- Measurement of dissolved oxygen, pH, temperature, pressure, exit-gas carbon dioxide and oxygen, mass flow and additional process parameters.
- Support for batch, fed-batch, fill-and-draw and continuous-harvest processes, alongside other operating strategies.
- Compatibility with diverse carbon sources and feed formulations tailored to customer requirements.
- Round-the-clock operations: shift operating system supporting production 24 hours a day, 365 days a year.
- Microbial capabilities: experience with bacteria, yeasts, filamentous fungi and microalgae, including both wild-type and genetically modified strains.
- Broth filling options: filling into tank containers, road tankers, intermediate bulk containers (IBCs) and other suitable formats.
- Direct transfer to the commercial-scale downstream processing (DSP) facility for further product recovery and processing.
- Direct transfer to our in-house pilot-scale or industrial-scale spray dryer.
Downstream
We operate a state-of-the-art, automated downstream processing facility supporting both pilot- and large-scale manufacturing. Our broad range of pilot-scale DSP equipment enables us to accurately simulate the key operating characteristics of the process. Our downstream platform includes a broad variety of filtration and separation technologies.
Details
- Decanter
- Vacuum drum filter
- Press filters
- Crossflow and spiral-wound membrane filtration systems (MF / UF / RO)
- Diafiltration and salt precipitation applications
- Continuous monitoring: 4 shifts, 24/7, all year round
- Option of setting up customized process equipment or process lines
Spray drying
Our pilot- and production-scale spray drying capabilities enable efficient development and optimization of drying processes for commercial manufacturing. With fermentation, downstream processing and spray drying all integrated within the same facility, we provide a seamless end-to-end production workflow.
Details
- Industrial spray dryer with 400 kg/h capacity.
- Pilot spray dryer for testing different drying parameters and carriers, providing excellent proof of concept.
Quality & Analytics
Our in-house molecular biology, microbiology, and analytical and quality control laboratories support every stage of a project, from strain and process development to the release of the finished product. Production runs in a food-grade facility with continuous monitoring across four shifts, 24 hours a day, all year round.
Details
- Food-grade facility certified to FSSC 22000.
- Halal, Kosher, ISO 9001 and ISO 14001 certified.
- In-house molecular biology, microbiology, analytical and quality control laboratories.
- Continuous monitoring: 4 shifts, 24/7, all year round.
